Figure 3.

Serotonergic, but Not Dopaminergic, Descending Axons Are Ablated by 5,7-DHT

Spinal cross-sections are shown (dorsal is up; asterisk indicates central canal).

(A–C) An intraperitoneal injection of 5,7-DHT ablates serotonergic (5-HT), but not TH1⁺, axons within 2 days (Mann-Whitney U-test; ^∗p = 0.0357).

(D–I) At 14 dpl, the number of axons rostral to the lesion is still strongly reduced after prior ablation (D–F), whereas caudal to the lesion, the low axon density is unaltered (G–I; Mann-Whitney U-test; ^∗∗p = 0.0022). The scale bar in (H) represents 50 μm.

See also Figure S3.