Figure 3.

Ketamine (Ket) inhibited the enhanced I_NaL induced by hypoxia (A, B) or H₂O₂ (C, D). (A) and (C), Representative whole-cell recordings of I_NaL in the absence of drug (Control) and before and after the application and washout of Ket (40 μmol/L) after treatment with 10 min of hypoxia (A) or 300 μmol/L H₂O₂ (C), respectively. (B) and (D), Summary data for the mean current density of I_NaL under different conditions. The data are expressed as the mean±SD (n=6 or 7). ^cP<0.01 vs Control; ^fP<0.01 vs hypoxia (B) or H₂O₂ (D).