Skip to main content
. 2015 Oct 12;36(11):1327–1336. doi: 10.1038/aps.2015.75

Figure 4.

Figure 4

Effects of TTX and ketamine (Ket) on the enhanced INCX induced by ATX. (A) and (D), Representative original currents recorded by a ramp pulse (inset) in the absence (Control) and presence of ATX 30 nmol/L before and after exposure to TTX 4 μmol/L (A) or Ket at 20, 40, or 80 μmol/L (D). (B) and (E), The Ni2+-sensitive INCX was obtained by subtracting the sweep after the application of 5 mmol/L NiCl2 (trace d for A; trace f for D) from sweeps before exposure to NiCl2. (C) and (F), Summary data for the current density of INCX measured at +50 mV and −100 mV. The data are expressed as the mean±SD (n=8). cP<0.01 vs Control; fP<0.01 vs ATX 30 nmol/L (ATX); iP<0.01 vs ATX plus Ket 20 μmol/L (ATX-K20, F); lP<0.01 ATX plus Ket 80 μmol/L (ATX-K80, F) vs ATX plus Ket 40 μmol/L (ATX-K40, F).