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S100A4 was negatively correlated with osteogenic gene expression and positively related to matrix degradation gene expression. The S100A4-RNAi cells exhibited significantly decreased S100A4 protein levels and significantly increased ALP and OCN mRNA expression levels compared with the parental and scrambled sequence groups (A, B). the overexpression of S100A4 elicited increases in S100A4 protein levels and significant elevations in MMP2 and MMP13 mRNA expressions (C, D). (cP<0.01).
