Figure 2. Distribution of charged residues along the sequences of yeast FG Nups.

Positive charges are shown in blue while negative charges are shown in red. The far right side of the figure represents the NPC wall. FG Nups are drawn in their extended form. It is clearly observable that not all domains of FG Nups are rich in charged residues, which implicitly proposes specific functionalities for different regions of each FG Nup (also discussed in⁵ and³⁹). Yeast is chosen as the example to represent the distribution of charged residues in the sequence of FG Nups since it is the most well studied species.