Figure 4. Comparison of central channel and periphery FG Nups in terms of number of charged residues embedded in LCR.

Data points are jittered to enable the reader to observe all of the data points. FG Nups fall into two distinct groups, with the central channel group possessing LCRs of lower than eight and the periphery group containing LCRs of larger than seven residues. The analysis is conducted on FG Nups from yeast and vertebrates with known location, i.e. central channel or periphery. Analyzed FG Nups are: [Central Channel] Nsp1 (blue), Nup49 (black), Nup57 (red), Nup145N (green), Nup62 (purple), Nup54 (yellow), Nup45 (gray), Nup58 (brown), [Cytoplasmic and Nuclear peripheries] Nup1 (orange), Nup2 (violet), Nup159 (cyan), Nup42 (blue), Nup100 (black), Nup116 (red), Nup98 (green), Nup358 (purple), Nup214 (yellow), Nup153 (gray), Nup50 (brown). Location information is obtained from⁵².