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. 2015 Nov 6;5:16084. doi: 10.1038/srep16084

Figure 5. Chronic ABC treatment rapidly alleviates the symptomatic akinetic behaviour in 6-OHDA pre-lesioned rats.

Figure 5

Stereotaxically-lesioned 6-OHDA rats compared to Sham-injected animals. Animals were chronically treated p.o. twice a day with ABC from D8 after lesion until D21 where akinesia tests were done (a). To check that akinetic behaviour was already manifested, initiation time and stepping tests were performed on day 7 (D7) (b). Positive effect of ABC at D21 in the initiation time (c) and stepping (d) tests. In a second set of experiments, animals were chronically treated p.o. twice a day with ABC from D8 after lesion until D10 (e) where initiation time test was done (f). L-dopa was used as reference drug. 6-OHDA or ABC did not have any effect in these behavioural tests when the control ipsilateral paw was assessed in the same rats in the initiation time and stepping tests. Values are mean ± s.e.m. n = 10 per condition. *P < 0.05, **P < 0.01, ***P < 0.001 versus 6-OHDA; ANOVA with Dunnett’s test. ABC 1: ACP 0.04 mg/kg + BCL 0.6 mg/kg. ABC 2: ACP 0.1 mg/kg + BCL 1.5 mg/kg. ABC 3: ACP 0.25 mg/kg + BCL 3.75 mg/kg. L-dopa: L-dopa 8 mg/kg + benserazide 12.5 mg/kg.