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. 2015 Nov 6;5:16256. doi: 10.1038/srep16256

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Colored maps indicating regional volume change (in %) of CBP group mean brain with respect to WT group are shown at axial slices Z = 2 (a), Z = 5 (b), Z = 9 (c), and Z = 14 (d) of the three-dimensional magnetic-resonance image. Brain regions can be grouped in three zones according to their behavior: regions evolved from the embryonic rhombencephalon that experiment no significant volume change (−0.68 ± 0.21%, blue regions), olfactory bulb that shows a low level of volume reduction (−6.28%, green regions), and regions developed from prosencephalon, which show a higher reduction (−12.51 ± 0.36%, orange regions).