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. 2015 Nov 6;5:16255. doi: 10.1038/srep16255

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GBM human xenografts with SF763 cells were done in the leg of nude mice. Pt-ctpy treatment was given intra- and peritumoraly at 2 mg/kg/day. In the combination experiments, Pt-ctpy was administered every 24 h for 5 days prior to single irradiation of 15 Gy and then 5 days after irradiation. (A) Representation of tumor growth kinetics in untreated group (NT) and in groups treated with radiation alone, Pt-ctpy alone or radiation + Pt-ctpy group. (B) Survival curves in these groups are significantly different.