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. 2015 Nov 6;5:16237. doi: 10.1038/srep16237

Figure 1. Major pharmacological classes promoting the neuronal differentiation of human NPCs.

Figure 1

(A) The primary screen results of 5 GSK-3 inhibitors (dash line boxed) and 2 statin molecules (dash and dot line boxed), shown are the whole well images of 384-well plate stained with DCX antibody. (B) Quantification of the percentages of DCX+ cells (DCX+%) as the results of effective compounds treatment. The DCX+ % was calculated as the number of DCX+ cells divided by the number of total cells. Compounds were tested at 2 μM concentration. Controls received equal volume of DMSO treatment. (C) Dose responsive curves of the example compounds from the two pharmacological classes. Scale bar, 200 μm. The differentiation rates were normalized to the DCX+% in the DMSO control wells.