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. 2015 Nov 6;5:16237. doi: 10.1038/srep16237

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Copyright © 2015, Macmillan Publishers Limited

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(A) Total cell count of the ReNCell VM cells after the treatment of various compounds. Kenpaullone significantly increased the cell number while mevastatin decreased it. (B) BrdU incorporation assay of the compound treated ReNCell VM cells. Kenpaullone significantly increased the number of proliferative cells while the other compounds had no effect. (C) Cell survival assay of the differentiated ReNCell VM cells treated with various compounds. Mevastatin significantly increase the number of apoptosis cells. Notably, apoptosis only occurred in undifferentiated cells, while not detected in the DCX+ neuronal cells (arrow head pointed). (D) Compound effect on the astrocyte differentiation of primary rat NPCs. None of the compounds significantly affected the differentiation rate. (E) Compound effect on the oligodendrocyte differentiation of primary rat NPCs. None of the compounds significantly affected the differentiation rate. In all the experiment the compound concentrations are: kenpaullone 3 μM; mevastatin 1 μM; LY364947 3 μM. Controls received equal volume of DMSO treatment. *P < 0.05. Scale bars, 50 μm.