Table 1. Experimental parameters and results.
| Rat | Pressure amplitude (MPa) in water | GABA |
N1P1 Magnitude |
N2P1 Magnitude |
MRI signal enhancement after Gd-DTPA | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| #Injections | Dose (kg/mg) | Max. suppression | % Suppression per mg/kg GABA | Suppression vs. GABA dose R2 | Max. suppression | % Suppression per mg/kg GABA | Suppression vs. GABA dose R2 | |||
| 1 | 0.65 | 12 | 0.8–64 | 51% | 0.7 ± 0.1 | 0.90 | 63% | 1.0 ± 0.1 | 0.81 | 23% |
| 2 | 0.64 | 6 | 0.4–24 | 82% | 2.9 ± 0.5 | 0.88 | 91% | 2.7 ± 1.0 | 0.58 | 83%† |
| 3 | 0.65 | 8 | 0.3–12 | 56% | 4.5 ± 1.0 | 0.69 | 89% | 8.6 ± 2.7 | 0.55 | 33%† |
| 4 | 0.60 | 5 | 0.5–8.8 | 42% | 5.2 ± 1.1 | 0.85 | 34% | 6.6 ± 1.1 | 0.90 | 28%† |
| 5 | 0.58 | 2 | 173, 519 | 88% | 0.17–0.26 | – | 83% | 0.16–0.39 | – | 22% |
| 6 | 0.58 | 1 | 423 | 35% | 0.08 | – | 42% | 0.1 | – | 6% |
| 7 | 0.58 | 1 | 485 | 38% | 0.08 | – | 63% | 0.13 | – | 30% |
| 8 | 0.61 | 1 | 423 | 99% | 0.23 | – | 82% | 0.19 | – | 91% |
| 9 | Control | 1 | 429 | −1% | 0.00 | – | −9% | −0.02 | – | – |
| 10 | Control | 1 | 393 | 7% | 0.02 | – | 9% | 0.02 | – | – |
| 11 | Control | 1 | 179 | 8% | 0.05 | – | 10% | 0.05 | – | – |
| 12 | Control | 1 | 191 | 4% | 0.02 | – | 4% | 0.02 | – | – |
†7T MRI; other animals were imaged at 3T.