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. 2015 Nov 6;5:16320. doi: 10.1038/srep16320

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Copyright © 2015, Macmillan Publishers Limited

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Mtb in the phagosomes could follow many pathways. Mtb, especially the virulent strains, is known to escape from the phagosome. Both phagosome bound and cytosolic Mtb may get trapped in the autophagosomes. Phagosome may also directly recruit LC3 to form a LAP vesicle. Further maturation of phagosomes, LAP or autophagosomes depends on recruitment of RAB7, which facilitates eventual fusion with the lysosome for degradation. Virulent strains of Mtb inhibit RAB7 recruitment on the phagosomes. This study shows, similar inhibition of RAB7 recruitment on autophagosomes and possibly on LAP by the virulent strain.