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. 2015 Nov 6;5:16392. doi: 10.1038/srep16392

Figure 1. Homozygous D104N polymorphisms (p.104NN) in endostatin are associated with reduced survival and a high metastatic rate.

Figure 1

(a) The survival rate was determined using the Kaplan-Meier method. The survival rate was significantly lower in osteosarcoma (OS) patients with p.104NN endostatin compared to OS patients who were heterozygous for the D104N polymorphism (p.104DN) or who harbored wild type endostatin. (b) The OS metastasis rate was higher in OS patients with p.104NN endostatin compared to OS patients with p.104DN or wild type endostatin.