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. 2015 Nov 6;5:16392. doi: 10.1038/srep16392

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(a) Serum endostatin levels were significantly higher in osteosarcoma (OS) patients (n = 236) compared to healthy individuals (n = 100). (b) The p.D104N does not affect serum endostatin levels in healthy individuals. (c) The p.D104N does not affect serum endostatin levels in OS patients. (d) The p.D104N does not affect endostatin expression in OS tissue. Immunohistochemistry assays were performed on primary tumor tissues from OS patients. Dark brown color indicates endostatin expression. Each bar represents the mean ± SD. Wild, wild type endostatin; p.104DN, heterozygous D104N polymorphism; p.104NN, homozygous D104N polymorphism.