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. 2015 Sep 9;78(5):520–526. doi: 10.1038/pr.2015.145

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Copyright © 2015 Official journal of the International Pediatric Research Foundation, Inc.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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No malignancies are induced in the nasal turbinates or brain after intranasal MSC treatment. Hematoxylin–eosin staining of brain and nasal turbinates sections from sham-operated, HI-vehicle, and HI-MSC mice at 14 mo post-HI. No neoplasia or lesions were observed. Examples of the nasal turbinates and cortical, hippocampal, and thalamic brain regions. n =10 per group; arrows = nasal/olfactory mucosa; star = olfactory nerve; circle = damaged hippocampus. Bar = 200 μm. HI, hypoxia–ischemia; MSC, mesenchymal stem cell.