Table 1.
Up-regulated excretion of at urine metabolites after gamma radiation exposures ranging from 0.5 to 10 Gy.
| Pre-vs.24 h Post-2.5 Gy | Fold-Change (Pre-vs.24 Post-Exposure) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||||
| m/z | Tret | Adduct | p(corr)[1] | Putative identity | 0.5 Gy | 1 Gy | 2.5 Gy | 5 Gy | 7.5 Gy | 10 Gy | |
| a | 135.0289 | 0.34 | [M-H]- | -0.776087 | Threonate | NS | NS | 17.3 (9.13, 32.1) | 19.9 (10.2, 95.8) | 2.25 (1.49, 3.87) | 3.49 (2.24, 6.57) |
| b | 165.0396 | 0.32 | [M-H]- | -0.731736 | Arabinonate | NS | -2.01 (-1.21, -3.59) | 4.55 (1.88, 10.3) | 11.6 (5.59, 96.0) | 3.86 (2.47, 7.55) | 5.36 (3.08, 11.4) |
| c | 128.9596 | 0.29 | [M-H]- | -0.723760 | ND | ND | > 10 | > 10 | > 10 | > 10 | |
| d | 355.0165 | 4.29 | [M-H]- | -0.712256 | NS | NS | > 10 | > 10 | 2.56 (1.82, 3.37) | 2.10 (1.38, 2.86) | |
| e | 241.0816 | 1.89 | [M-H]- | -0.690459 | Thymidine* | ND | ND | > 10 | > 10 | > 10 | > 10 |
| f | 112.9857 | 0.29 | [M-H]- | -0.680258 | Fragment of d | ND | ND | > 10 | > 10 | 2.43 (1.49, 3.79) | 2.38 (1.16, 4.08) |
| g | 209.0303 | 0.33 | [M-H]- | -0.663502 | Glucarate | ND | ND | > 10 | 12.5 (5.94, 32.6) | 24.4 (11.2, 398) | > 10 |
| h | 195.0490 | 0.32 | [M-H]- | -0.641262 | NS | NS | NS | 3.02 (2.07, 4.29) | 3.32 (2.43, 4.30) | 4.60 (2.81, 6.51) | |
| i | 251.0516 | 0.32 | [M-H]- | -0.629689 | ND | ND | > 10 | > 10 | > 10 | > 10 | |
| j | 176.9351 | 0.34 | [M-H]- | -0.533538 | ND | ND | > 10 | > 10 | 45.5 (17.3, 297) | > 10 | |
| k | 167.0195 | 0.36 | [M-H]- | 0.154537 | Uric Acid* | NS | NS | NS | 2.22 (1.18, 3.58) | > 10 | 15.4 (4.13, 49.9) |
| l | 201.9351 | 0.29 | [M+H]+ | -0.581992 | NS | NS | 11.6 (5.23, 113) | > 10 | > 10 | 6.60 (3.17, 415) | |
| m | 228.1009 | 0.36 | [M+H]+ | -0.527531 | NS | NS | > 10 | > 10 | 1.84 (1.42, 2.38) | 3.12 (1.87, 7.47) | |
| n | 207.1114 | 2.21 | [M+H]+ | -0.488026 | ND | NS | > 10 | > 10 | > 10 | > 10 | |
| o | 112.0502 | 0.35 | [M+H]+ | -0.48s7919 | Cytosine* | NS | NS | 5.49 (3.41, 12.2) | 5.18 (3.25, 10.8) | 2.56 (2.00, 3.29) | 3.43 (2.55, 4.76) |
| p | 455.1881 | 0.35 | [M+H]+ | -0.418781 | ND | ND | > 10 | > 10 | > 10 | > 10 | |
| q | 132.0769 | 0.35 | [M+H]+ | -0.389817 | Creatine* | > 10 | ND | > 10 | > 10 | > 10 | 3.43 (2.55, 4.76) |
| r | 162.1126 | 0.32 | [M+H]+ | -0.306065 | Carnitine* | NS | NS | 3.20 (1.41, 28.6) | 5.80 (3.01, 24.5) | 5.95 (2.72, 39.8) | 4.18 (1.78, 11.1) |
| s | 90.0543 | 0.34 | [M+H]+ | -0.292752 | Alanine or Sarcosine | NS | ND | > 10 | > 10 | > 10 | > 10 |
| t | 143.1176 | 0.36 | [M+H]+ | -0.199188 | NS | NS | 3.26 (1.40, 17.6) | 2.81 (1.35, 8.0) | 2.16 (1.33, 3.29) | 3.37 (2.31, 4.88) | |
| u | 141.0665 | 0.35 | [M+H]+ | -0.185771 | Methylimidazoleacetic acid | NS | NS | 1.67 (1.29, 2.16) | 1.52 (1.11, 2.21) | 1.55 (1.18, 2.02) | 1.70 (1.43, 2.00) |
*
Confirmed identity: CHEBI:17748 thymidine, CHEBI:27226 uric acid, CHEBI:16040 cytosine, CHEBI:16919 creatine, CHEBI:17126 carnitine
abbreviations: m/z, mass/charge; Tret, Retention Time; NS, Non-Significant; ND, Not Detected