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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Neuron. 2015 Nov 4;88(3):514–527. doi: 10.1016/j.neuron.2015.09.049

Figure 2.

Figure 2

Misexpression of egl-5 transforms the ALM neurons to PLM-like cells. (A) Three categories of ALM morphology in animals carrying mec-3p::egl-5 transgene. For category I, ALM grows a posterior neurite that is located subdorsally. For category II, the ALM posterior neurite crosses the midline and then runs subventrally together with PLM neurites. For category III, the entire ALM neuron lies subventrally. For both categories II and III, the ALM posterior and PLM anterior neurites are intertwined with each other but often deviate apart after running together for a certain length. (B) The anterior neurite of ALM neurons stopped prematurely (arrow) after branching into the nerve ring in animals carrying the mec-3p::egl-5 transgene. In these transgenic animals, FLP (indicated by triangle) and PVD neurons ectopically express the TRN marker mec-17p::GFP (Zheng et al., unpublished). (C) The length of ALM posterior neurites from various strains of transgenic animals normalized to the diameter of the ALM cell body on the A-P axis (n > 50 for each strain).