Table 1. Lipid compositions (%) of synthetic liposome membranes.
Lipid compositions for different cellular compartments are approximate, and based on the following references: plasma membrane and early endosomal membrane: Gruenberg (2003); van Meer et al. (2008); multivesicular bodies: Gillooly et al. (2000); Gruenberg (2003); Gruenberg & Stenmark (2004); Möbius et al. (2003); late endosomal membranes: Kobayashi et al. (2002); Kobayashi et al. (1999); Kobayashi et al. (1998); Möbius et al. (2003); van Meer et al. (2008).
| Cellular compartment/lipid ratio | Lipid (%) | ||||||||
| POPC | POPE | POPG | POPS | PI3P | BMP | C1P | Chol | Total | |
| Plasma membrane | 45 | 10 | – | 5 | 0 | – | – | 40 | 100 |
| Early endosomal membrane | 45 | 10 | – | 15 | 0 | – | – | 30 | 100 |
| Multivesicular bodies | 30 | 20 | – | 10 | 10 | – | – | 30 | 100 |
| Late endosomal membranes | 40 | 20 | – | – | 5 | 15 | – | 20 | 100 |
| PC :PG : Chol | 40 | – | 40 | – | – | – | – | 20 | 100 |
| PC : PS : Chol | 40 | – | – | 40 | – | – | – | 20 | 100 |
| PC : BMP : Chol | 40 | – | – | – | – | 40 | – | 20 | 100 |
| PC : C1P : Chol | 40 | – | – | – | – | – | 40 | 20 | 100 |
POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine; POPS, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine; POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]; C1P, N-palmitoyl-ceramide-1-phosphate; PI3P, phosphatidylinositol-3-phophate; BMP, oleoyl bis(monoacylglycero)phosphate (S,S) isomer; Chol, cholesterol; PC, phosphatidylcholine; PS, phosphatidylserine; PG, phosphatidylglycerol.