Fig. 2. PrsS, like σS, protects S. aureus against killing by DNA-damaging agents. Viability of the USA300 WT, prsS mutant (prsS), prsS complement (C), and prsS E215A/E216A inactive complement (IC) strains was assessed in the presence of 50 mM MMS (a) or 1.3 M hydrogen peroxide (b). C.f.u. counts were determined for strains pre- and 30 min (a) or 5 min (b) post exposure to these agents, and are averaged (mean) from three independent experiments. Error bars are shown±sem; *P<0.05 using Student’s t-test.
