Fig. 1. DENV-4 TVP-376 is lethal in AG129 mice. (a) Kaplan–Meier survival curves of AG129-mice infected with 10^6.0, 10^7.0 or 10^7.5 p.f.u. D2S10 or TVP-376. #, Mouse developed paralysis. (b) Mean percentage weight lost ± se relative to animal weight of TVP-376-infected mice (10^7.0 p.f.u.: ANOVA P < 0.0001; Dunnett's post-test, significant at 3–6 days p.i.). (c) Viraemia titres (mean ± se) of mice infected with 10^6.0 and 10^7.0 p.f.u. TVP-376.