Fig. 7. AGB6 mice are susceptible to D2S10 and TVP-376 infection. (a) Kaplan–Meier survival curves of AGB6 mice infected with 10^6.4 or 10^7.4 p.f.u. D2S10 or TVP-376. (b) Mean percentage weight lost ± se relative to animal weight. ANOVA and Dunnett's post-test: 10^6.4 p.f.u. D2S10, P < 0.0001 (significant at 3 and 4 days p.i.); 10^6.4 p.f.u. TVP-376, P < 0.0001 (significant at 4–6 days p.i.); 10^7.4 p.f.u. TVP-376, P < 0.01 (significant at 3 and 4 days p.i.); t-test of 10^7.4 p.f.u. D2S10 between 0 and 3 days p.i., P < 0.0001. (c) Viraemia titres of AGB6 mice assessed at 3 days p.i. (d) Infectivity titres of tissues harvested from AGB6 mice infected with 10^7.4 p.f.u. TVP-376 at moribund state (3–4 days p.i.) (n = 4). Data represent individual titres (symbols), mean daily titre (lines), and statistical significance (asterisks) analysed using ANOVA with Tukey's post-test.