Fig. 4. Histology of brain tissue from YFV-17D-infected mice. IFNAR−/− mice were intramuscularly inoculated with 104 p.f.u. YFV-17D and brain tissue was harvested at disease onset (day 7 or 8 p.i.) for mice exhibiting viscerotropic or neurotropic disease, or day 8 p.i. for mice with no clinical signs of disease. Hippocampal sections from (a) uninfected, (b) no clinical signs, (c) neurotropic and (d) viscerotropic mice were histologically stained with HE. Immune infiltrates appear as dark clusters of cells. Sections are representative of at least two mice per condition. Bar, 100 µm.
