Fig. 1. IVIG protects BALB/c mice from WNV encephalitis. (a) Mice were infected intraperitoneally with the indicated doses of WNV and monitored for survival. (b, c) Mice infected with 104 p.f.u. WNV were given PBS, 4 mg IVIG or WNV-IVIG at 24 h p.i. (b) or 25 mg IVIG, desialylated or deglycosylated IVIG, or an IVIG adsorbed to be free of WNV E-gp antibodies and monitored for survival (c). (d) Mice infected with 105 p.f.u. WNV were given 4 mg WNV-IVIG, 25 mg IVIG (1×) at 24 h p.i. and some mice received a second dose (2×) of IVIG at day 9 p.i. n = 6–10 mice per group. Statistically significant values are indicated within each plot.
