Fig. 2. IVIG controls virus replication in the CNS after high-dose WNV infection. BALB/c mice infected with 105 p.f.u. WNV were treated with PBS, IVIG (25 mg) or WNV-IVIG (4 mg) at 24 h p.i. At the indicated time points, (a) spleens and (b) brains were analysed for WNV RNA by TaqMan PCR. All IVIG-treated mice died by day 23 p.i.; PBS-treated mice died by days 9–10 p.i. Data representative of three experiments; n = 3 mice per time point. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
