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Fig. 4. IVIG controls virus replication in BALB/c mice inoculated with a low dose (104 p.f.u.) of WNV. At the indicated time points, (a) spleens and (b) brains were isolated from mice treated with PBS, IVIG (25 mg) or WNV-IVIG (4 mg) at 24 h p.i., and analysed for WNV RNA using TaqMan PCR. Data representative of three experiments; n = 3 mice per time point. *P<0.05, **P<0.01.