Fig. 4. Claudin-1 expression in CC-LP-1 cells promotes HCVpp infection. CC-LP-1 (black) and claudin-null 293T (white) cells were transduced to express claudin-1 and inoculated with HCVpp expressing a range of envelope glycoproteins. Huh-7 hepatoma cells (grey) were included as a control. Claudin-1 expression promoted HCVpp infection of 293T and CC-LP-1 cells. Only CC-LP-1 supported HCVpp infection in the absence of claudin-1 overexpression. N = 3 independent experiments.