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. 2015 Jun;161(Pt 6):1198–1210. doi: 10.1099/mic.0.000082

Table 2. Stress response genes upregulated in Y. pestis ΔphoP during flea infection.

Criteria for significance: ≥ 2-fold difference, P ≤ 0.05 or ≥ 1.5-fold difference, P ≤ 0.001. Fold-change values in parentheses not significant based on P value. Genes in bold type are associated with an upstream consensus PhoP-binding site and are predicted or have been shown to be directly regulated by PhoP (Harari et al., 2010; Li et al., 2008; Perez et al., 2009).

Relative expression (fold-change; WT versus ΔphoP)
during growth in:
Gene ID Gene name Predicted function of gene product Flea LB (flow cell) LB (exponential) LB (stationary)
Envelope stress/general stress response
y0066 cpxP Periplasmic stress adaptor protein  − 5.5 ( − 2.0) ( − 2.0) 4.5
y0137 degQ Endopeptidase; HtrA family protein
quality control and stress response
 − 1.7 1.2  − 1.2 1.0
y0295 hslV Endopeptidase; protein quality control  − 2.1  − 1.2  − 1.2 1.0
y0419 rpoH RNA polymerase factor sigma-32  − 2.1  − 1.1  − 1.1  − 1.3
y1265 kdpA Potassium-transport, osmotic stress  − 2.1 1.2  − 1.0  − 1.3
y1266 kdpB Potassium-transport, osmotic stress  − 3.1 1.1  − 1.2 (1.5)
y1868 htpX Heat-shock protein  − 2.8  − 1.1  − 1.3 1.3
y3706 dnaK Heat-shock protein  − 3.0  − 1.3 1.1 1.2
y4101 ibpA Heat-shock protein chaperone  − 5.2 1.3 1.2 1.3
y4102 ibpB Heat-shock protein  − 3.9 (1.6)  − 1.1 1.4
Tellurite resistance genes
y0555 terZ Tellurite resistance, stress response protein  − 3.7  − 1.3  − 1.2  − 1.4
y0556 terA Tellurite resistance, stress response protein  − 2.5 1.0 1.0 1.4
y0557 terB Tellurite resistance, stress response protein  − 2.2 1.2  − 1.2 1.0
y0558 terC Tellurite resistance, stress response protein  − 2.4 1.0  − 1.1 1.1
TA
Y1074 relE/parE family addiction toxin module  − 3.8 ( − 1.7) ( − 2.0) 1.0
Y1075 phD family addiction antitoxin module  − 2.5 ( − 1.6) ( − 1.8) 1.0
y3266 mqsA MqsA antitoxin  − 3.5 ( − 1.8)  − 1.4 1.0
YPO0882* mqsR MqsR toxin  − 4.5 ( − 2.6)  − 1.4 1.0
YPO1087* HigB2 toxin  − 2.3  − 1.2 1.0 1.1
YhcN family (DUF1471) multiple stress resistance
y0666 yhcN Multiple stress resistance protein  − 9.3 ( − 1.5)  − 1.3 1.1
y1667 Multiple stress resistance protein  − 12.4 ( − 1.9)  − 1.0  − 1.2

* Gene not annotated in Y. pestis KIM (YPO number indicates Y. pestis CO92 homologue).