Table 2.
Clinical domains covered by the CHRIS study. Classes have been adapted by the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). Relevant diagnostic codes are reported in parenthesis when matching the assessment modality
| Domain | Field (ICD-10 code) | Mode of assessment (source), questionnaire; instrumental assessment |
|---|---|---|
| Diseases of the circulatory system | Myocardial infarction; heart failure; cardiac arrhythmias (I20-25) | CAPI (PhenX); 10″ and 20′ ECG |
| Essential hypertension (I10) | CAPI (PhenX); blood pressure measurement | |
| Stroke (I64); including transient cerebral ischemic attack (G45) | CAPI Jackson Heart Study Screening Questionnaire [70] | |
| Peripheral vascular disease (I73); pulmonary embolism (I26); deep venous thrombosis | CAPI (PhenX) | |
| Endocrine, nutritional and metabolic diseases | Diabetes mellitus (E10-14) | CAPI KORA study [71]; serum glucose, plasma HbA1c |
| Disorders of thyroid gland (E00-07) | CAPI; serum TSH, FT4, and FT3 | |
| Obesity and localized adiposity (E65-66) | Body Mass Index, Bioimpedance | |
| Diseases of the genitourinary system | Renal insufficiency (N00-19) | CAPI (PhenX); serum creatinine, urinary albumin-to-creatinine ratio |
| Diseases of the nervous system: extrapyramidal and movement disorders | Parkinson’s disease (G20) | CAPI [17] |
| Essential Tremor (G25.0) | Digitalized spiralography | |
| Restless Leg Syndrome (G25.8) | CASI RLS Diagnosis and Rating Scale [72] | |
| Diseases of the nervous system: other | Migraine (G43) | CASI Int’l Classif. Headache Disorders (ICHD-II) |
| Sleep disorders (sleep quality and behavior) (G47); chronotype (G47.2) | CASI Pittsburgh Sleep Quality Index (PSQI) [20], R.E.M. Sleep Behavior Questionnaire (RBDQ) [73], Munich Chronotype Questionnaire (MCTQ) [28] | |
| Pain (R52.0) including pain sensitivity | CAPI Pain Sensitivity Questionnaire [27]; pressure and tension gauge algometer | |
| Chronic pain | CAPI Chronic pain questionnaire | |
| Psychiatric disorders | Anxiety (F40-41) | CASI State-Trait Anxiety Inventory (STAI Y-2) [19] |
| Depression (F32-33) | CASI Center for Epidemiologic Studies of the National Institute of Mental Health Depression scale (CES-D) [18] | |
| Hypomania and mood (F30-39) | Paper-based, self-administered; MINI International Neuropsychiatric Interview (M.I.N.I.) [32]; HCL-32 questionnaire for Energy, Activity and Mood [35] | |
| Cognition and autonomic function | Cognition impairment | CAPI Mini-Mental State Examination (MMSE) [30] |
| Autonomic dysfunction | CASI Composite Autonomic Symptom Score (COMPASS 31) [31] | |
| Disturbances of smell (R43) | Sniffin’ sticks [45] |
CAPI computer assisted personal interview, CASI computer assisted self interview, SQ screening questionnaire, PhenX based on PhenXToolkit standards (https://www.phenxtoolkit.org/index.php)