Table 5.
Body weight, weight of spleen, spleno-somatic index and number of parasites in BALB/c mice following various treatments
| Treatment | Body weight | Weight of spleen | Spleno-somatic index | No of parasites |
|---|---|---|---|---|
| Az | 22.11 ± 0.54 | 0.18 ± 0.021c | 0.84 ± 0.10c | 37.3 ± 6.4c |
| Rc | 21.78 ± 0.89 | 0.23 ± 0.021b | 1.04 ± 0.08b | 58.4 ± 9.8b |
| Az + Rc | 20.50 ± 0.45 | 0.15 ± 0.006a | 0.73 ± 0.02a | 26.4 ± 0.7a |
| Amphotericin B | 21.00 ± 1.00 | 0.13 ± 0.005a | 0.74 ± 0.06a | 25.7 ± 0.5a |
| Pentostam | 21.00 ± 0.58 | 0.14 ± 0.010a | 0.75 ± 0.07a | 26.1 ± 0.4a |
| PBS | 21.00 ± 1.73 | 0.37 ± 0.014d | 1.83 ± 0.21d | 145.7 ± 6.7d |
| ANOVA | ||||
| F | 2.1332 | 35.255 | 71.214 | 46.987 |
| df | 5 | 5 | 5 | 5 |
| P | 0.3245 | 0.0001 | 0.0000 | 0.0000 |
Means in the same column followed by the same superscript show no significant difference between them
Az, A. indica; Rc, R. communis; Az + Rc, A. indica and R. communis (combination therapy); PBS, phosphate buffered saline (negative control); Pentostam, standard drug (positive control); Amphotericin B, standard drug (positive control)