Table 1.
The effect of ADM treatment on the up-regulated cytokines in tubal ectopic pregnancy (tEP) oviducts (N = 5)
| Symbol | Protein name | tEP vs control | tEP + ADM vs tEP | ||
|---|---|---|---|---|---|
| Fold change | P value^ | Fold change | P value# | ||
| Pro-inflammatory cytokines | |||||
| GM-CSF | Granulocyte-macrophage colony-stimulating factor | 2.5173 | 0.032* | 0.3204 | 0.032* |
| IL-7 | Interleukin 7 | 2.5057 | 0.032* | 0.2167 | 0.043* |
| IFN-gamma | Interferon-gamma | 2.1281 | 0.032* | 0.5332 | 0.080 |
| TNF-beta | Tumour necrosis factor-beta | 1.8817 | 0.016* | 0.4897 | 0.043* |
| Anti-inflammatory cytokines | |||||
| IL-10 | Interleukin 10 | 1.8760 | 0.008* | 0.6194 | 0.043* |
| HGF | Hepatocyte growth factor | 1.5196 | 0.032* | 0.7346 | 0.043* |
| Pro- and anti-inflammatory cytokines | |||||
| IL-4 | Interleukin 4 | 2.3493 | 0.032* | 0.3941 | 0.043* |
| IL-6 | Interleukin 6 | 4.1152 | 0.016* | 0.1135 | 0.043* |
Cytokines which were significantly up-regulated (p < 0.05) in tEP oviducts (N = 5) compared to controls (N = 5) are listed. To study the effect of ADM on the expression of these up-regulated cytokines, tEP oviducts were treated with 100 nM ADM for 24 h. (*statistically significant, P < 0.05; ^Mann–Whitney U test; #Wilcoxon signed rank test)