FIGURE 1.

Detrimental effect of Tyk2 deficiency on DSS-induced colitis. (A–C) C57BL/6N (WT) and Tyk2^−/− mice were treated with 2% DSS for 7 d, followed by 2 d of water. (A) Weight loss was determined daily and is displayed relative to initial weight. Data are derived from five independent experiments with n = 23 (WT) or n = 19 (Tyk2^−/−) total. Results are given as mean values ± SEM. (B) Histological scores for days 0, 1, 2 (each n = 3), 3, 6 (each n = 6), and 9 (n = 12) of DSS treatment. Results for individual mice and mean values are depicted. (C) WT and Tyk2^−/− colon tissue sections were stained with H&E. Representative images are shown for untreated mice and for mice on day 9 of DSS treatment. *p < 0.05, ***p < 0.001.