Table 1.
Shows the serum biomarkers of bone and cartilage metabolism at the end of 5 and 10 weeks of the study
| 5 weeks | |||||
|---|---|---|---|---|---|
| Parameter | Unit | Sham | MM + veh | MM + Zol | MM + PTH |
| Osteocalcin | ng/mL | 32.8 ± 5.0 | 32.1 ± 5.1 | 24.3 ± 2.1** | 60.4 ± 16.9** |
| P1NP | ng/mL | 277.2 ± 73.7 | 274.8 ± 44.2 | 243.8 ± 43.8 | 285.5 ± 44.1 |
| CTX-I | ng/mL | 22.5 ± 4.4 | 25.0 ± 5.0 | 28.9 ± 4.7 | 30.6 ± 6.3 |
| CTX-II | ng/mL | 30.5 ± 9.9 | 39.3 ± 8.7a | 13.2 ± 8.5** | 30.4 ± 4.0* |
| 10 weeks | |||||
| Osteocalcin | ng/mL | 47.1 ± 11.5 | 38.1 ± 9.3 | 27.8 ± 11.5 | 30.7 ± 3.9 |
| P1NP | ng/mL | 146.0 ± 22.0 | 174.7 ± 26.1 | 134.8 ± 29.7 | 163.7 ± 26.8 |
| CTX-I | ng/mL | 36.7 ± 3.1 | 40.5 ± 7.9 | 49.3 ± 7.6 | 36.2 ± 4.1 |
| CTX-II | ng/mL | 14.4 ± 4.1 | 20.9 ± 5.6a | 11.6 ± 3.2* | 21.4 ± 5.3 |
Sham, sham control group, MM + veh medial meniscectomy (MM) vehicle-treated group, MM + Zol MM + zoledronate group, MM + PTH MM + parathyroid hormone group, P1NP procollagen type 1 N-terminal propeptide, CTX-I cross-linked type I collagen C-terminal telopeptide, CTX-II C-terminal telopeptide of type II collagen
* p < 0.05 or ** < 0.01 relative to MM + veh rats
a p < 0.05 relative to sham rats