Table 3.
Univariate and multivariate analyses of the survival of HCC patients
| Covariate | n | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95 % CI | P value | HR | 95 % CI | P value | ||
| Gender | 0.710 | 0.758 | |||||
| Male | 48 | 1.000 | 1.000 | ||||
| Female | 6 | 1.254 | 0.381–4.126 | 1.232 | 0.326–4.654 | ||
| Age (years) | 0.812 | 0.371 | |||||
| ≤50 | 17 | 1.000 | 1.000 | ||||
| >50 | 37 | 1.099 | 0.506–2.387 | 0.671 | 0.280–1.609 | ||
| Tumor size (cm) | 0.037 | 0.062 | |||||
| ≤5 | 27 | 1.000 | 1.000 | ||||
| >5 | 27 | 2.170 | 1.046–4.504 | 2.148 | 0.964 | 4.785 | |
| TNM stage | 0.105 | 0.329 | |||||
| I | 6 | 1.000 | 1.000 | ||||
| II | 37 | 1.087 | 0.323–3.659 | ||||
| III | 11 | 2.395 | 0.633–9.058 | 1.459 | 0.683–3.116 | ||
| Cytoplasmic PRMT5 | 0.033 | 0.029 | |||||
| Low | 36 | 1.000 | 1.000 | ||||
| High | 18 | 2.175 | 1.067–4.435 | 2.411 | 1.094–5.313 | ||
| Nuclear PRMT5 | 0.963 | 0.691 | |||||
| Low | 40 | 1.000 | 1.000 | ||||
| High | 14 | 1.020 | 0.439–2.369 | 1.228 | 0.446–3.380 | ||
The Cox proportional hazards regression model was used for univariate and multivariate analyses to study the effects of the clinicopathological variables and PRMT5 expression on survival
HR hazard ratio, CI confidence interval