Table 3.
The pattern of combined P. falciparum dhfr–dhps haplotypes
| Pfdhps haplotypes | Pfdhfr haplotypes | Total | |||||
|---|---|---|---|---|---|---|---|
| Wild-type | Double | Triple | |||||
| CNCSI | CICNI | CIRSI | CNRNI | CIRNI | |||
| Wildtype | SAKAA | 0 | 4 | 0 | 2 | 20 | 26 |
| Single | AAKAA | 1 | 3 | 0 | 4 | 16 | 24 |
| SAEAA | 0 | 0 | 0 | 0 | 4 | 4 | |
| SAKAS | 0 | 0 | 0 | 0 | 1 | 1 | |
| Double | SGEAA | 0 | 5 | 0 | 0 | 31 | 36 |
| AAKAS | 0 | 0 | 0 | 0 | 2 | 2 | |
| Triple | SGEGA | 0 | 1 | 0 | 0 | 32 | 33 |
| AGEAA | 2 | 14 | 1 | 10 | 69 | 96 | |
| Quadruple | AGEGA | 0 | 1 | 0 | 0 | 11 | 12 |
| Total | 3 | 28 | 1 | 16 | 186 | 234 | |
The overall numbers (absolute) parasite haplotypes on the Pfdhfr–Pfdhps genes in the samples successfully analysed (n = 234). Of all the combined haplotypes, the quintuple CIRNI-SGEAA, sextuple CIRNI-AGEAA, CIRNI-SGEGA were more frequently detected
Bold underline indicates the amino acid changes, while SAKAA and CNCSI represent the wildtype haplotype for Pfdhps and Pfdhfr, respectively