Table 3.

Evidence for a cation-π interaction with ACh at 10:1 α6β2^‡.

	EC50 (uM)	nH	Imax uA	Fold	N
Trp	0.169 ± 0.003	1.36 ± 0.03	0.28–14.9	0.94	12
MeTrp	0.110 ± 0.002	1.18 ± 0.02	0.19–19.4	0.61	12
4-F1Trp	0.210 ± 0.006	1.25 ± 0.04	0.71–6.92	1.17	9
5-F1Trp	0.81 ± 0.01	1.37 ± 0.03	1.39–14.4	4.50	10
6-F1Trp	0.66 ± 0.02	1.30 ± 0.04	0.18–4.28	3.67	10
BrTrp	0.53 ± 0.01	1.32 ± 0.04	0.22–15.1	2.94	14
F2Trp	1.41 ± 0.02	1.43 ± 0.02	0.76–9.33	7.83	9
CNTrp	15.1 ± 0.6	1.25 ± 0.05	0.31–13.3	83.89	14
F3Trp	4.5 ± 0.2	1.04 ± 0.03	0.09–1.94	25.00	12