Table 4.

Lack of evidence for cation-π interactions with nicotine and TC299423 at Trp B in α6β2^‡.

Nic	EC50 (µM)	nH	Imax (µA)	Fold	N
Trp	0.150 ± 0.006	1.43 ± 0.06	0.09–5.8	1	12
MeTrp	0.094 ± 0.003	1.36 ± 0.05	0.31–3.95	0.63	11
F1Trp	0.75 ± 0.02	1.39 ± 0.06	0.07–2.06	5.00	12
BrTrp	0.98 ± 0.03	1.42 ± 0.04	0.08–5.65	6.53	14
F2Trp	0.78 ± 0.04	1.30 ± 0.06	0.32–2.13	5.20	10
F3Trp	0.89 ± 0.02	1.28 ± 0.03	0.05–1.05	5.93	10
TC299423	EC50 (µM)	nH	Imax (µA)	Fold	N
Trp	0.093 ± 0.004	1.09 ± 0.04	0.33–3.78	1	11
MeTrp	0.073 ± 0.004	0.92 ± 0.03	0.15–2.35	0.78	13
F1Trp	0.22 ± 0.01	1.01 ± 0.04	0.27–3.49	2.37	15
BrTrp	0.25 ± 0.008	1.01 ± 0.03	0.1–7.71	2.69	11
F2Trp	0.138 ± 0.006	0.98 ± 0.04	0.06–1.87	1.48	11
F3Trp	0.63 ± 0.03	0.90 ± 0.03	0.05–0.28	6.77	13