Table 4.

Crude and adjusted odds ratios for the association between the area under the curve of intraoperative hypotension during cardiac surgery and occurrence of postoperative delirium. *Results were adjusted for EuroSCORE, duration of surgery and cardiopulmonary bypass, total intraoperative fluid, cumulative duration of vasopressors and inotropes. ^# Estimates per 1000 mm Hg² min² AUC² increase of intraoperative hypotension depth and/or duration. ^‡Considered statistically significant when P<0.01 and multiple testing was taken into account. ^†Interquartile ranges: MAP<60 mm Hg (774–1861 mm Hg min); MAP<50 mm Hg (114–448 mm Hg min); Decrease MAP decrease >30% relative to baseline (763–3653 mm Hg min); Decrease MAP decrease >40% relative to baseline (183–1570 mm Hg min). OR, odds ratio; CI, confidence interval; MAP, mean arterial pressure

Intraoperative hypotension definition	Unadjusted analysis					Adjusted analysis*
	OR#	99% CI	P-value‡	75th - 25th percentile		OR#	99% CI	P-value‡	75th - 25th percentile
				OR†	99% CI				OR†	99% CI
MAP<60 mm Hg	1.05	1.01–1.09	<0.01	1.14	1.10–1.18	1.04	0.99–1.10	0.04	1.12	1.07–1.16
MAP<50 mm Hg	1.22	1.02–1.66	0.04	1.04	0.81–1.33	1.14	0.98–1.53	0.09	1.03	0.80–1.31
MAP decrease >30% relative to baseline	1.00	0.996–1.01	0.23	1.03	1.03–1.04	1.00	0.99–1.01	0.45	1.02	1.02–1.03
MAP decrease >40% relative to baseline	1.00	0.990–1.02	0.32	1.01	1.00–1.02	1.00	0.99–1.02	0.55	1.01	1.00–1.02