Table 3.
Genotype and minor allele frequencies of dopamine-related loci.
| Polymorphism | Genotypes N (%) | Allele Frequency | HWE p-value | |||
|---|---|---|---|---|---|---|
| NCAM1-TTC12-ANKK1-DRD2 region loci | ||||||
| NCAM1 | ||||||
| rs618114 Frequency |
GG 156 (58.2) |
GA / AG 85 (31.7) |
AA 8 (3.0) |
G 0.81 |
A 0.19 |
0.44 |
| TTC12 | ||||||
| rs2303380 Frequency |
GG 24 (9.0) |
GA / AG 109 (40.7) |
AA 124 (46.3) |
G 0.29 |
A 0.71 |
0.99 |
| rs2282511 Frequency |
CC 155 (57.8) |
CA / AC 78 (29.1) |
AA 21 (7.8) |
C 0.78 |
A 0.22 |
0.03 |
| ANKK1 | ||||||
| rs877138 Frequency |
GG 18 (6.7) |
GA / AG 77 (28.7) |
AA 164 (61.2) |
G 0.21 |
A 0.79 |
0.06 |
| rs17115439 Frequency |
TT 99 (36.9) |
TC / CT 107 (39.9) |
CC 51 (19.0) |
T 0.61 |
C 0.39 |
0.04 |
| rs4938013 Frequency |
CC 165 (61.6) |
CA / AC 78 (29.1) |
AA 18 (6.7) |
C 0.79 |
A 0.21 |
0.05 |
| rs4938015 Frequency |
TT 101 (37.7) |
TC / CT 107 (39.9) |
CC 51 (19.0) |
T 0.61 |
C 0.39 |
0.02 |
| rs11604671 Frequency |
GG 203 (75.7) |
GA / AG 51 (19.0) |
AA 51 (19.0) |
G 0.90 |
A 0.10 |
0.33 |
| DRD2 | ||||||
| rs1079597 Frequency |
GG 190 (70.9) |
GA / AG 63 (23.5) |
AA 8 (3.0) |
G 0.85 |
A 0.15 |
0.31 |
| rs6277 Frequency |
TT 3 (1.1) |
TC / CT 51 (19.0) |
CC 207 (77.2) |
T 0.11 |
C 0.89 |
1 |
| rs1800497 Frequency |
TT 34 (12.7) |
TC / CT 112 (41.8) |
CC 111 (41.4) |
T 0.34 |
C 0.66 |
0.24 |
| rs1799732 Frequency |
Del/Del 56 (20.9) |
C.Del/Del.C 86 (32.1) |
CC 94 (35.1) |
Del 0.37 |
C 0.63 |
3.59 E-05 |
| Exploratory loci | ||||||
| COMT | ||||||
| rs4680 Frequency |
GG 121 (45.1) |
GA / AG 110 (41.0) |
AA 25 (9.3) |
G 0.70 |
A 0.30 |
.71 |
| DBH | ||||||
| rs1611115 Frequency |
TT 5 (1.9) |
TC / CT 76 (28.4) |
CC 178 (66.4) |
T 0.16 |
C 0.84 |
.39 |
Note. Table shows the genotypes and frequencies for each marker (in order of chromosomal location). All loci are single nucleotide polymorphisms except for rs1799732 which is an InDel polymorphism. Proportions do not sum to 100 to allow for the accurate depiction of missingness in the data.