Table 5.

Unstandardized estimates from main effects models predicting FTND and WISDM intermediate phenotypes from genetic variants

					WISDM Subscales
			FTND		Automaticity		Craving		Locus of Control		Tolerance
			β	SE	β	SE	β	SE	β	SE	β	SE
Haplotype Block 1 [rs2282511 (TTC12), rs877138 (ANKK1)]
CA			0.49*	0.20	0.38*	0.01	0.22	0.16	0.23	0.15	0.22	0.15
AG			−0.50†	0.21	−0.34†	0.16	−0.23	0.17	−0.23	0.16	−0.20	0.16
Haplotype Block 2 [rs17115439 (ANKK1) and rs4938013 (ANKK1)
TC			0.23	0.18	0.07	0.14	0.02	0.14	0.10	0.14	−0.03	0.14
TA			−0.45†	0.21	−0.34†	0.16	−0.20	0.17	−0.22	0.16	−0.19	0.16
CC			0.10	0.18	0.17	0.13	0.12	0.14	0.07	0.13	0.16	0.13
Haplotype Block 3 [rs4938015 (ANKK1) and rs11604671 (ANKK1)]
TG			−0.16	0.18	−0.19	0.13	−0.14	0.14	−0.06	0.13	−0.18	0.13
CG			0.09	0.19	0.17	0.15	0.14	0.15	0.01	0.14	0.20	0.14
Polymorphism	Gene	MA
rs618114	NCAM1	A	−0.07	0.00	−0.16	0.18	0.03	0.19	0.04	0.18	−0.07	0.18
rs2303380	TTC12	G	−0.30	0.01	−0.32†	0.15	−0.16	0.16	−0.05	0.15	−0.15	0.15
rs1079597	DRD2	A	−0.07	0.00	−0.39†	0.19	−0.25	0.20	−0.13	0.19	−0.29	0.18
rs6277	DRD2	T	0.02	0.00	−0.12	0.22	−0.18	0.23	−0.12	0.22	−0.04	0.22
rs1800497	DRD2	T	0.30	0.01	−0.19	0.14	−0.18	0.15	−0.04	0.14	−0.23	0.14
rs4680	COMT	A	−0.02	0.20	−0.17	0.15	−0.13	0.16	−0.04	0.15	−0.07	0.15
rs1611115	DBH	T	0.59†	0.25	0.55*	0.19	0.52*	0.20	0.41†	0.19	0.49*	0.19

Note. FTND=Fagerstrom Test of Nicotine Dependence; WISDM = Wisconsin Inventory of Smoking Motives; COMT = Catechol-O-methyltransferase gene; DBH = Dopamine beta-hydroxylase gene; ANKK1 = Ankyrin repeat and kinase domain containing 1 gene; DRD2 = Dopamine D2 receptor gene; NCAM1 = Neural cell adhesion molecule 1 gene; TTC12 = Tetratricopeptide Repeat Domain 12 gene. Block 1 = rs2282511 (TTC12), rs877138 (ANKK1); Block 2 = rs17115439 (ANKK1) and rs4938013 (ANKK1); Block 3 rs4938015 (ANKK1) and rs11604671 (ANKK1).

^*p < .01,

^†p < .05.