Table 1.

Participant characteristics of lung cancer cases and controls

Variants	Discovery (n = 3767)				P value	Replication (n = 6536)				P value
	Control (n = 1953)		Case (n = 1814)			Control (n = 3553)		Case (n = 2983)
Age (years)
0–64	846	43.32	711	39.2	0.01	2286	64.34	1819	60.98	0.005
≥65	1107	56.68	1103	60.80		1267	35.66	1164	39.02
Gender
Male	1492	76.4	1428	78.72	0.09	2397	67.46	2082	69.80	0.04
Female	461	23.6	386	21.28		1156	32.54	901	30.20
Smoking status
Never	628	32.16	138	7.61	<0.0001	865	24.35	136	4.56	<0.0001
Former	840	43.01	774	42.67		1279	36.00	964	32.32
Current	485	24.83	902	49.72		1409	39.66	1883	63.12
Smoking pack-years
0	628	32.16	138	7.61	<0.0001	866	24.37	136	4.56	<0.0001
1–15	462	23.66	123	6.78		541	15.23	241	8.08
16–30	353	18.07	278	15.33		748	21.05	601	20.15
31–50	342	17.51	625	34.45		865	24.35	1149	38.52
>50	168	8.6	650	35.83		533	15.00	856	28.70
Histology
Squamous			466	25.69				307	10.29
Adenocarcinoma			753	41.51				620	20.78
Other			566	31.20				226	7.58
Missing			29	1.6				1830	61.35