Table 2.
Associations between polymorphisms and risk of lung cancer
| SNP | Control | Case | Crude | Adjusteda | ||||
|---|---|---|---|---|---|---|---|---|
| Allele | N | N | % | OR (95% CI) | P | OR (95% CI) | P | |
| Discovery | ||||||||
| rs588765 | C/C | 789 | 827 | 45.59 | 1 | 1 | ||
| C/T | 919 | 771 | 42.5 | 0.80 (0.70–0.92) | 0.001 | 0.86 (0.74–1.01) | 0.06 | |
| T/T | 245 | 216 | 11.91 | 0.84 (0.68–1.04) | 0.10 | 0.91 (0.72–1.16) | 0.47 | |
| Trend test | 0.01 | 0.16 | ||||||
| rs16969968 | G/G | 750 | 514 | 28.34 | 1 | 1 | ||
| A/G | 917 | 904 | 49.83 | 1.44 (1.24–1.66) | <0.0001 | 1.45 (1.23–1.71) | <0.0001 | |
| A/A | 286 | 396 | 21.83 | 2.02 (1.67–2.44) | <0.0001 | 1.87 (1.50–2.33) | <0.0001 | |
| Trend test | <0.0001 | <0.0001 | ||||||
| Replication | ||||||||
| rs588765 | C/C | 1154 | 1070 | 35.87 | 1 | 1 | ||
| C/T | 1753 | 1414 | 47.40 | 0.87 (0.78–0.97) | 0.01 | 0.85 (0.76–0.96) | 0.01 | |
| T/T | 646 | 499 | 16.73 | 0.83 (0.72–0.96) | 0.01 | 0.81 (0.70–0.95) | 0.01 | |
| Trend test | 0.005 | 0.002 | ||||||
| rs16969968 | G/G | 1554 | 1088 | 36.47 | 1 | |||
| A/G | 1599 | 1405 | 47.10 | 1.26 (1.13–1.40) | <0.0001 | 1.22 (1.09–1.37) | 0.0005 | |
| A/A | 400 | 490 | 16.43 | 1.75 (1.50–2.04) | <0.0001 | 1.72 (1.46–2.03) | <0.0001 | |
| Trend test | <0.0001 | <0.0001 | ||||||
aAdjusted for age at diagnosis/interview, sex, smoking status, smoking pack-years and the significant PCs.