Table 3.
Association between the rs588765-rs16969968 haplotype and risk of lung cancer
| Haplotype | Control | Case | Crude | Adjusteda | ||||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | OR (95%CI) | P | OR (95% CI) | P | |
| Discovery | ||||||||
| CG/CG | 122 | 6.25 | 71 | 3.91 | 1 | 1 | ||
| CG/TG | 383 | 19.61 | 227 | 12.51 | 1.02 (0.73–1.42) | 0.91 | 0.96 (0.66–1.40) | 0.83 |
| TG/TG | 245 | 12.54 | 216 | 11.91 | 1.52 (1.07–2.14) | 0.02 | 1.50 (1.01–2.23) | 0.04 |
| TG/CA | 536 | 27.44 | 544 | 29.99 | 1.74 (1.27–2.39) | 0.001 | 1.75 (1.22–2.50) | 0.002 |
| CG/CA | 381 | 19.51 | 360 | 19.85 | 1.62 (1.17–2.25) | 0.004 | 1.49 (1.02–2.17) | 0.04 |
| CA/CA | 286 | 14.64 | 396 | 21.83 | 2.38 (1.71–3.31) | <0.0001 | 2.12 (1.46–3.07) | <0.0001 |
| Replication | ||||||||
| CG/CG | 208 | 5.85 | 115 | 3.86 | 1 | 1 | ||
| CG/TG | 700 | 19.70 | 474 | 15.89 | 1.23 (0.95–1.58) | 0.12 | 1.14 (0.86–0.86) | 0.36 |
| TG/TG | 646 | 18.18 | 499 | 16.73 | 1.40 (1.08–1.81) | 0.01 | 1.26 (0.96–1.66) | 0.09 |
| TG/CA | 1053 | 29.64 | 940 | 31.51 | 1.62 (1.27–2.06) | 0.0001 | 1.43 (1.10–1.85) | 0.01 |
| CG/CA | 546 | 15.37 | 465 | 15.59 | 1.54 (1.19–2.00) | 0.001 | 1.40 (1.07–1.85) | 0.01 |
| CA/CA | 400 | 11.26 | 490 | 16.43 | 2.22 (1.70–2.88) | <0.0001 | 2.01 (1.51–2.67) | <0.0001 |
aAdjusted for age at diagnosis/interview, sex, smoking status and smoking pack-years, the significant PCs.