Table 4.
Association between haplotype and risk of lung cancer in never, former and current smokers
| Smoking | Haplotype | Control | Case | Crude | Adjusteda | ||||
|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | OR (95% CI) | P | OR (95%CI) | P | ||
| Discovery | |||||||||
| No | CG/CG + CG/TG | 150 | 23.89 | 29 | 21.01 | 1 | 1 | ||
| TG/TG | 76 | 12.10 | 15 | 10.87 | 1.02 (0.52–2.02) | 0.95 | 1.01 (0.50–2.05) | 0.97 | |
| TG/CA | 181 | 28.82 | 42 | 30.43 | 1.20 (0.71–2.02) | 0.49 | 1.23 (0.71–2.13) | 0.47 | |
| CG/CA | 124 | 19.75 | 23 | 16.67 | 0.96 (0.53–1.74) | 0.89 | 1.00 (0.53–1.89) | 0.99 | |
| CA/CA | 97 | 15.45 | 29 | 21.01 | 1.55 (0.87–2.75) | 0.14 | 1.75 (0.96–3.19) | 0.07 | |
| Former | CG/CG + CG/TG | 225 | 26.79 | 141 | 18.22 | 1 | 1 | ||
| TG/TG | 107 | 12.74 | 97 | 12.53 | 1.45 (1.02–2.05) | 0.04 | 1.66 (1.13–2.44) | 0.01 | |
| TG/CA | 230 | 27.38 | 233 | 30.10 | 1.62 (1.22–2.14) | 0.001 | 1.76 (1.29–2.39) | 0.0003 | |
| CG/CA | 150 | 17.86 | 142 | 18.35 | 1.51 (1.11–2.06) | 0.01 | 1.41 (0.99–2.00) | 0.05 | |
| CA/CA | 128 | 15.24 | 161 | 20.80 | 2.01 (1.47–2.75) | <0.0001 | 1.78 (1.25–2.53) | 0.001 | |
| Current | CG/CG + CG/TG | 130 | 26.80 | 128 | 14.19 | 1 | 1 | ||
| TG/TG | 62 | 12.78 | 104 | 11.53 | 1.70 (1.14–2.54) | 0.01 | 1.65 (1.06–2.58) | 0.03 | |
| TG/CA | 125 | 25.77 | 269 | 29.82 | 2.19 (1.58–3.02) | <0.0001 | 2.10 (1.48–2.97) | <0.0001 | |
| CG/CA | 107 | 22.06 | 195 | 21.62 | 1.85 (1.32–2.60) | 0.0004 | 1.86 (1.27–2.73) | 0.001 | |
| CA/CA | 61 | 12.58 | 206 | 22.84 | 3.43 (2.36–4.99) | <0.0001 | 3.16 (2.12–4.72) | <0.0001 | |
| Replication | |||||||||
| No | CG/CG + CG/TG | 241 | 27.86 | 29 | 21.32 | 1 | 1 | ||
| TG/TG | 144 | 16.65 | 32 | 23.53 | 1.85 (1.07–3.18) | 0.03 | 1.85 (1.06–3.24) | 0.03 | |
| TG/CA | 248 | 28.67 | 36 | 26.47 | 1.21 (0.72–2.03) | 0.48 | 1.29 (0.76–2.21) | 0.35 | |
| CG/CA | 138 | 15.95 | 15 | 11.03 | 0.90 (0.47–1.74) | 0.76 | 0.96 (0.49–1.87) | 0.89 | |
| CA/CA | 94 | 10.87 | 24 | 17.65 | 2.12 (1.18–3.83) | 0.01 | 2.10 (1.12–3.96) | 0.02 | |
| Former | CG/CG + CG/TG | 327 | 25.57 | 192 | 19.92 | 1 | 1 | ||
| TG/TG | 236 | 18.45 | 165 | 17.12 | 1.19 (0.91–1.56) | 0.20 | 1.16 (0.88–1.54) | 0.29 | |
| TG/CA | 391 | 30.57 | 297 | 30.81 | 1.29 (1.02–1.63) | 0.03 | 1.32 (1.04–1.68) | 0.02 | |
| CG/CA | 179 | 14.00 | 153 | 15.87 | 1.46 (1.10–1.93) | 0.01 | 1.51 (1.13–2.01) | 0.01 | |
| CA/CA | 146 | 11.42 | 157 | 16.29 | 1.83 (1.37–2.44) | <0.0001 | 1.90 (1.40–2.57) | <0.0001 | |
| Current | CG/CG + CG/TG | 340 | 24.13 | 368 | 19.54 | 1 | 1 | ||
| TG/TG | 266 | 18.88 | 302 | 16.04 | 1.05 (0.84–1.31) | 0.67 | 1.03 (0.82–1.28) | 0.82 | |
| TG/CA | 414 | 29.38 | 607 | 32.24 | 1.36 (1.12–1.64) | 0.002 | 1.30 (1.06–1.58) | 0.01 | |
| CG/CA | 229 | 16.25 | 297 | 15.77 | 1.20 (0.96–1.50) | 0.11 | 1.19 (0.94–1.50) | 0.14 | |
| CA/CA | 160 | 11.36 | 309 | 16.41 | 1.78 (1.40–2.27) | <0.0001 | 1.77 (1.38–2.26) | <0.0001 | |
aAdjusted for age at diagnosis/interview, sex, smoking pack-years and the significant PCs.