Table 5.
Interaction of haplotypes and smoking status in the risk of lung cancer
| Haplotype | Control | Case | Crude | Adjusteda | |||||
|---|---|---|---|---|---|---|---|---|---|
| Smoking | N | % | N | % | OR (95% CI) | P | OR (95% CI) | P | |
| Discovery | |||||||||
| CG/CG + CG/TG | No | 150 | 7.68 | 29 | 1.60 | 1 | 1 | ||
| Former | 225 | 11.52 | 141 | 7.77 | 3.24 (2.07–5.08) | <0.0001 | 0.65 (0.31–1.37) | 0.25 | |
| Current | 130 | 6.66 | 128 | 7.06 | 5.09 (3.19–8.12) | <0.0001 | 0.36 (0.13–0.99) | 0.05 | |
| TG/TG | No | 76 | 3.89 | 15 | 0.83 | 1.02 (0.52–2.02) | 0.95 | 1.01 (0.50–2.05) | 0.97 |
| Former | 107 | 5.48 | 97 | 5.35 | 4.69 (2.89–7.60) | <0.0001 | 0.77 (0.32–1.84) | 0.56 | |
| Current | 62 | 3.17 | 104 | 5.73 | 8.68 (5.23–14.40) | <0.0001 | 0.50 (0.12–1.98) | 0.32 | |
| TG/CA | No | 181 | 9.27 | 42 | 2.32 | 1.20 (0.71–2.02) | 0.49 | 1.23 (0.71–2.13) | 0.47 |
| Former | 230 | 11.78 | 233 | 12.84 | 5.24 (3.38–8.11) | <0.0001 | 0.88 (0.45–1.73) | 0.70 | |
| Current | 125 | 6.40 | 269 | 14.83 | 11.13 (7.09–17.46) | <0.0001 | 1.48 (0.64–3.40) | 0.36 | |
| CG/CA | No | 124 | 6.35 | 23 | 1.27 | 0.96 (0.53–1.74) | 0.89 | 1.00 (0.53–1.89) | 0.99 |
| Former | 150 | 7.68 | 142 | 7.83 | 4.90 (3.09–7.75) | <0.0001 | 1.08 (0.47–2.48) | 0.86 | |
| Current | 107 | 5.48 | 195 | 10.75 | 9.43 (5.94–14.96) | <0.0001 | 0.30 (0.10–0.88) | 0.03 | |
| CA/CA | No | 97 | 4.97 | 29 | 1.60 | 1.55 (0.87–2.75) | 0.14 | 1.75 (0.96–3.18) | 0.07 |
| Former | 128 | 6.55 | 161 | 8.88 | 6.51 (4.11–10.31) | <0.0001 | 0.85 (0.36–1.99) | 0.71 | |
| Current | 61 | 3.12 | 206 | 11.36 | 17.46 (10.70–28.49) | <0.0001 | 3.93 (1.32–11.71) | 0.01 | |
| Replication | |||||||||
| CG/CG + CG/TG | No | 241 | 6.78 | 29 | 0.97 | 1 | 1 | ||
| Former | 327 | 9.20 | 192 | 6.44 | 4.88 (3.19–7.46) | <0.0001 | 2.23 (1.18–4.22) | 0.01 | |
| Current | 340 | 9.57 | 368 | 12.34 | 8.99 (5.96–13.59) | <0.0001 | 3.61 (1.89–6.89) | <0.0001 | |
| TG/TG | No | 144 | 4.05 | 32 | 1.07 | 1.85 (1.07–3.18) | 0.03 | 1.85 (1.06–3.24) | 0.03 |
| Former | 236 | 6.64 | 165 | 5.53 | 5.81 (3.77–8.96) | <0.0001 | 2.67 (1.31–5.44) | 0.01 | |
| Current | 266 | 7.49 | 302 | 10.12 | 9.44 (6.21–14.35) | <0.0001 | 2.55 (1.22–5.36) | 0.01 | |
| TG/CA | No | 248 | 6.98 | 36 | 1.21 | 1.21 (0.72–2.03) | 0.48 | 1.29 (0.76–2.21) | 0.35 |
| Former | 391 | 11.00 | 297 | 9.96 | 6.31 (4.17–9.55) | <0.0001 | 3.19 (1.81–5.64) | <0.0001 | |
| Current | 414 | 11.65 | 607 | 20.35 | 12.18 (8.18–18.27) | <0.0001 | 3.28 (1.80–5.96) | 0.0001 | |
| CG/CA | No | 138 | 3.88 | 15 | 0.50 | 0.90 (0.47–1.74) | 0.76 | 0.96 (0.49–1.87) | 0.89 |
| Former | 179 | 5.04 | 153 | 5.13 | 7.10 (4.57–11.05) | <0.0001 | 4.82 (2.35–9.88) | <0.0001 | |
| Current | 229 | 6.45 | 297 | 9.96 | 10.78 (7.07–16.44) | <0.0001 | 4.14 (2.02–8.48) | <0.0001 | |
| CA/CA | No | 94 | 2.65 | 24 | 0.80 | 2.12 (1.18–3.83) | 0.01 | 2.10 (1.12–3.96) | 0.02 |
| Former | 146 | 4.11 | 157 | 5.26 | 8.94 (5.72–13.96) | <0.0001 | 3.02 (1.42–6.42) | 0.004 | |
| Current | 160 | 4.50 | 309 | 10.36 | 16.05 (10.44–24.67) | <0.0001 | 6.88 (3.09–15.34) | <0.0001 | |
aAdjusted for age at diagnosis/interview, sex, smoking pack-years and the significant PCs.