. 2015 Aug 16;36(11):1275–1283. doi: 10.1093/carcin/bgv118

Table 6.

Association between haplotypes and risk of lung adenocarcinoma and lung squamous cell carcinoma

Haplotype	Controls		Cases
	(n = 1953)		Lung adenocarcinoma (n = 753)						Lung squamous cell carcinoma (n = 466)
					Crude		Adjusted^a				Crude		Adjusted^a
	N	%	N	%	OR (95%CI)	P	OR (95%CI)	P	N	%	OR (95%CI)	P	OR (95%CI)	P
Discovery
CG/CG + CG/TG	505	25.86	114	15.14	1		1		84	18.03	1		1
TG/TG	245	12.54	88	11.69	1.59 (1.16–2.19)	0.004	1.64 (1.17–2.30)	0.004	60	12.88	1.47 (1.02– 2.12)	0.04	1.49 (0.98–2.29)	0.06
TG/CA	536	27.44	235	31.21	1.94 (1.51–2.51)	<0.0001	2.01 (1.53–2.64)	<0.0001	131	28.11	1.47 (1.09– 1.98)	0.01	1.59 (1.13–2.23)	0.01
CG/CA	381	19.51	158	20.98	1.84 (1.40–2.42)	<0.0001	1.85 (1.38–2.49)	<0.0001	104	22.32	1.64 (1.20– 2.25)	0.002	1.57 (1.08–2.28)	0.02
CA/CA	286	14.64	158	20.98	2.45 (1.85–3.24)	<0.0001	2.30 (1.70–3.11)	<0.0001	87	18.67	1.83 (1.31– 2.55)	0.0004	1.69 (1.16–2.47)	0.01
Replication
CG/CG + CG/TG	908	25.56	134	21.61	1		1		61	19.87	1		1
TG/TG	646	18.18	100	16.13	1.05 (0.79–1.39)	0.74	0.95 (0.69–1.30)	0.74	57	18.57	1.31 (0.90– 1.91)	0.15	1.23 (0.81–1.86)	0.33
TG/CA	1053	29.64	194	31.29	1.25 (0.99–1.58)	0.07	1.32 (1.01–1.74)	0.04	103	33.55	1.46 (1.05– 2.02)	0.03	1.50 (1.04–2.17)	0.03
CG/CA	546	15.37	100	16.13	1.24 (0.94–1.64)	0.13	1.35 (0.98–1.85)	0.06	36	11.73	0.98 (0.64– 1.50)	0.93	0.99 (0.62–1.57)	0.95
CA/CA	400	11.26	92	14.84	1.56 (1.17–2.08)	0.003	1.60 (1.14–2.25)	0.01	50	16.29	1.86 (1.26– 2.75)	0.002	1.86 (1.19–2.90)	0.01

^aAdjusted for age at diagnosis/interview, sex, smoking status, smoking pack-years, and the significant PCs.