Table 4.
Rate of US Emergency Department Visits per 100,000 US Outpatient Prescriptions Dispensed, Stratified by Hypersensitivity Reaction Severity Category and Fluoroquinolone, 2004–2010
| Hypersensitivity Reaction Severity Category | Fluoroquinolone | Estimated Number of ED Visits per 100,000 Prescriptions (95% CI) | Rate Ratioa (95% CI) | Rate Ratiob (95% CI) |
|---|---|---|---|---|
| Mild | Ciprofloxacin | 18.4 (13.9–22.9) | Referent | -------- |
| Levofloxacin | 25.0 (18.8–31.1) | 1.4 (0.9–1.8) | Referent | |
| Moxifloxacin | 82.4 (53.9–110.9) | 4.5 (2.6–6.4) | 3.3 (1.9–4.7) | |
| Moderate to Severec | Ciprofloxacin | 8.0 (6.0–10.0) | Referent | -------- |
| Levofloxacin | 15.8 (11.6–20.0) | 2.0 (1.3–2.7) | Referent | |
| Moxifloxacin | 58.9 (40.5–77.3) | 7.4 (4.4–10.4) | 3.7 (2.2–5.3) | |
| All Hypersensitivity Reaction Categories | Ciprofloxacin | 26.3 (20.8–31.9) | Referent | -------- |
| Levofloxacin | 40.8 (31.5–50.0) | 1.5 (1.1–2.0) | Referent | |
| Moxifloxacin | 141.3 (99.9–182.7) | 5.4 (3.4–7.3) | 3.5 (2.2–4.7) |
a
Each rate ratio was calculated by dividing the rate of ED visits per 100,000 prescriptions for moxifloxacin and levofloxacin by the rate estimated for ciprofloxacin (referent-lowest incidence across categories).
b
Each rate ratio was calculated by dividing the rate of ED visits per 100,000 prescriptions for moxifloxacin by the rate estimated for levofloxacin.
c
Moderate to severe reactions are pooled cases of moderate and severe reactions from the NEISS-CADES system.