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. 2015 May 29;4(12):e1050574. doi: 10.1080/2162402X.2015.1050574

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Figure 2. — Effects of MPO+ and CD8+ tumor infiltration on overall survival in patients with CRC. Kaplan–Meier overall survival curves were designed according to MPO+ and CD8+ tumor infiltration in patients with CRC (n = 1131 ). Cut-off values established by regression tree analysis, as previously reported,^16,24 were 60 cells/punch for MPO and 10 cells/punch for CD8 cell infiltration. Cumulative effects of tumor infiltration by MPO+ and CD8+ cells were also explored. A: Kaplan–Meier overall survival curves of tumors with low MPO+ and low CD8+ cell infiltration (MPO CD8 - line) in comparison to all other three groups (MPO^high/CD8^low, MPO^low/CD8^high, and MPO^high/CD8^high, continuous line) (p < 0.0001). B: MPO CD8+ – line refers to tumors with MPO^low/CD8^low infiltration (284 deaths observed in 767 patients). MPO CD8 −+ line refers to tumors with MPO^low/CD8^high infiltrates (63 deaths observed in 200 patients). MPO CD8 ++ line refers to tumors with MPO^high/CD8^high infiltration (15 deaths observed in 48 patients) and MPO CD8 +− line refers to CRC with MPO^high/CD8^low cell infiltration (35 deaths observed in 116 patients) (p < 0.0001).