Table 2.
Immune response to pneumococcal vaccine in the intention-to-treat population
| Day 0 GMCs | Day 30 GMCs | Day 30 GMFI | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Serotype | Treatment vaccine N = 811 | Control vaccine N = 808 | p value | Treatment vaccine N = 811 | Control vaccine N = 808 | p value | Treatment vaccine N = 811 | Control vaccine N = 808 | p value |
| 1 | 12.17(11.35–13.06) | 12.06(11.24–12.94) | 0.8535 | 45.69(42.84–48.73) | 45.16(42.22–48.29) | 0.8039 | 3.75(3.47–4.05) | 3.74(3.46–4.06) | 0.9658 |
| 2 | 17.04(15.86–18.32) | 16.66(15.56–17.84) | 0.6533 | 121.01(111.87–130.89) | 102.61(94.91–110.94) | 0.0035 | 7.10(6.58–7.66) | 6.16(5.71–6.64) | 0.0091 |
| 3 | 30.93(27.22–35.15) | 31.73(28.15–35.77) | 0.7752 | 155.10(144.75–166.18) | 117.99(110.58–125.89) | <0.0001 | 5.01(4.44–5.66) | 3.72(3.32–4.17) | 0.0004 |
| 4 | 21.31(20.00–22.70) | 20.40(19.17–21.72) | 0.3379 | 103.62(97.04–110.64) | 76.62(71.89–81.66) | <0.0001 | 4.86(4.54–5.21) | 3.76(3.52–4.01) | <0.0001 |
| 5 | 24.21(22.93–25.56) | 24.28(23.05–25.57) | 0.9394 | 79.60(74.98–84.51) | 77.43(73.02–82.12) | 0.5177 | 3.29(3.11–3.48) | 3.19(3.02–3.37) | 0.4487 |
| 6B | 3.55(3.07–4.11) | 3.53(3.05–4.09) | 0.9620 | 17.27(15.07–19.79) | 21.63(19.03–24.58) | 0.0183 | 4.90(4.26–5.64) | 6.16(5.39–7.04) | 0.0192 |
| 7F | 36.74(34.35–39.30) | 37.00(34.73–39.42) | 0.8789 | 154.62(145.51–164.31) | 158.09(148.61–168.18) | 0.6158 | 4.21(3.94–4.50) | 4.27(4.02–4.54) | 0.7436 |
| 8 | 7.49(6.86–8.18) | 7.35(6.71–8.04) | 0.7626 | 110.58(103.34–118.33) | 110.86(103.35–118.92) | 0.9595 | 14.76(13.34–16.34) | 15.09(13.68–16.64) | 0.7594 |
| 9N | 6.07(5.52–6.68) | 6.02(5.45–6.64) | 0.8968 | 91.21(85.33–97.50) | 88.53(82.70–94.77) | 0.5387 | 15.02(13.78–16.38) | 14.71(13.43–16.13) | 0.7457 |
| 9V | 12.18(10.87–13.66) | 10.24(9.03–11.61) | 0.0450 | 112.21(104.31–120.71) | 89.31(82.84–96.28) | <0.0001 | 9.21(8.33–10.19) | 8.72(7.84–9.71) | 0.4689 |
| 10A | 26.52(25.04–28.09) | 25.69(24.36–27.10) | 0.4272 | 96.98(89.43–105.17) | 64.55(59.99–69.45) | <0.0001 | 3.66(3.42–3.91) | 2.51(2.37–2.67) | <0.0001 |
| 11A | 22.78(20.76–25.00) | 23.20(21.27–25.31) | 0.7778 | 103.84(97.90–110.14) | 91.53(86.17–97.22) | 0.0034 | 4.56(4.18–4.97) | 3.94(3.64–4.27) | 0.0157 |
| 12F | 30.94(28.31–33.82) | 32.50(30.01–35.19) | 0.4207 | 153.70(141.80–166.60) | 153.91(140.42–168.68) | 0.9829 | 4.97(4.52–5.46) | 4.74(4.31–5.21) | 0.4875 |
| 14 | 23.36(22.02–24.78) | 25.13(23.52–26.86) | 0.1057 | 73.45(68.27–79.01) | 77.34(72.08–83.00) | 0.3179 | 3.14(2.95–3.35) | 3.08(2.88–3.28) | 0.6417 |
| 15B | 34.97(33.10–36.94) | 33.63(31.82–35.56) | 0.3287 | 155.20(144.74–166.42) | 135.45(126.63–144.87) | 0.0059 | 4.44(4.16–4.74) | 4.03(3.77–4.30) | 0.0370 |
| 17F | 19.07(17.87–20.34) | 18.01(16.98–19.11) | 0.2022 | 119.81(103.02–117.05) | 108.94(102.40–115.90) | 0.8606 | 5.76(5.38–6.17) | 6.05(5.66–6.47) | 0.3141 |
| 18C | 6.56(5.75–7.48) | 6.77(6.03–7.61) | 0.7148 | 72.27(67.20–77.73) | 64.11(59.76–68.78) | 0.0202 | 11.02(9.84–12.35) | 9.46(8.54–10.49) | 0.0512 |
| 19A | 31.22(29.22–33.36) | 29.36(27.34–31.53) | 0.2149 | 129.03(119.09–139.81) | 111.73(103.15–121.03) | 0.0127 | 4.13(3.56–4.07) | 3.81(3.56–4.07) | 0.1006 |
| 19F | 25.80(24.11–27.60) | 23.86(22.28–25.55) | 0.1120 | 115.10(106.03–124.94) | 110.70(102.02–120.12) | 0.5089 | 4.46(4.15–4.80) | 4.64(4.30–5.00) | 0.4681 |
| 20 | 28.72(26.48–31.14) | 28.26(26.25–30.42) | 0.7723 | 152.95(142.27–164.44) | 137.14(125.03–150.42) | 0.0682 | 5.33(4.92–5.77) | 4.85(4.47–5.27) | 0.1091 |
| 22F | 37.01(35.15–38.97) | 35.66(33.92–37.49) | 0.3102 | 118.73(111.93–125.94) | 108.63(102.55–115.06) | 0.0342 | 3.21(3.02–3.41) | 3.05(2.88–3.22) | 0.2167 |
| 23F | 25.31(23.81–26.90) | 25.01(23.54–26.57) | 0.7867 | 85.16(79.03–91.78) | 80.88(74.90–87.35) | 0.3455 | 3.37(3.15–3.59) | 3.23(3.03–3.45) | 0.4012 |
| 33F | 7.93(7.15–8.78) | 7.58(6.89–8.35) | 0.5340 | 114.16(106.35–122.54) | 92.52(86.31–99.17) | <0.0001 | 14.40(13.15–15.78) | 12.20(11.17–13.34) | 0.0108 |