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. 2015 Mar 6;11(8):1983–1990. doi: 10.1080/21645515.2015.1011987

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Figure 4. — Induced antibody response by 3 different DNA vaccine vectors. (A) Serum anti-HA IgG responses measured by ELISA against HA as the coating antigen from H1N1pdm09, 1968 H3N2 and a swine H1N2 isolate, heterologous to the DNA vaccine. Group II was immunized with influenza genes inserted into the conventional pSSI vector. Group III and IV were immunized with influenza genes inserted into the new vectors NTC8385-VA1 and NTC9385R, respectively. (B-D) Vaccine-induced hemagglutination inhibition antibody responses in rabbit sera against (B) H1N1pdm09, (C) 1968 H2N3 and (D) swine H1N1 isolates were measured. The HI titers are provided as the geometric mean titer. The arrows indicate vaccination time points and each curve or bar represents the mean with SEM of each group of 4–5 rabbits.